By Ned Swanson, MD, President & Chief Medical Officer, PolarityBio.

As regenerative therapies advance in wound care, most conversations center on what a therapy contains - cells, matrix, or signaling components. But there’s another important component - where those elements come from.

The source of tissue matters because it influences how a therapy interacts with the body, how well it’s tolerated, and how closely it mimics natural healing processes. In regenerative medicine, the distinction between autologous and allogeneic approaches is essential.

By Ned Swanson, MD, President & Chief Medical Officer, PolarityBio.

As regenerative treatments become more common in wound care, one distinction is critical: cellular versus acellular therapies. These terms often get used interchangeably, but biologically they represent very different approaches. Understanding that difference is key to knowing whether a therapy can truly support tissue regeneration.